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ISSN : 1226-0088(Print)
ISSN : 2288-7253(Online)
Membrane Journal Vol.24 No.2 pp.113-122

상전이를 통한 Poly(L-lactide) 스캐폴드 막의 제조에서의 용매의 효과

조 유 송*, 김 영 경*, 구 자 경*,†, 박 종 순**
*한국기술교육대학교 에너지․신소재․화학공학부, **㈜글로원

Effects of Solvent on the Fabrication of Poly(L-lactide) Scaffold Membranes through Phase Inversion

Ja-Kyung Koo*,†, Yu Song Cho*, Young Kyoung Kim*, Jong Soon Park**
*School of Energy٠Materials and Chemical Engineering, Korea University of Technology and Education,
1600 Chungjeolno, Byungchonmyun, Chonan, Chungnam 330-708, Korea
**GLO-ONE Co. LTD, 190 Maesilro, Sojeongmyeon, Sejong City, Korea
(Received March 12, 2014, Revised March 24, 2014, Accepted March 26, 2014)


Porous poly(L-lactic acid)(PLLA) scaffold membranes were prepared via. phase separation process.Chloroform, dichloromethane and 1,4-dioxane were used as solvent and, ethyl alcohol was used as non-solvent.Morphologies, mechanical properties and mass transfer characteristics of the scaffold membranes were investigated throughSEM, stress-strain test and glucose diffusion test. The scaffold membranes obtained from the casting solutions with chloroformand with dichloromethane showed similar morphologies. They showed sponge-like porous structure with the pore sizein the range of 3-10μm and, their porosities were in 50-80% range. Using 1,4-dioxane as solvent, nano-fibrous scaffoldmembranes with porosities over 80% were fabricated. When the polymer content in the solution with 1,4-dioxane was loweredto 4%, highly porous, macroporous and nano-fibrous scaffold membranes were obtained. The size of the macroporewas tens of the microns and the porosity was around 90%. These results indicate that the solvent has significant effect onthe scaffold membrane structure and, that scaffold membranes with various structures can be fabricated through phase separationmethod by choosing solvent and by controlling polymer concentration in the casting solution.